Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation of post‐transcriptional RNA (...) editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

This volume is a newly revised and updated edition of _Evolution and Consciousness_ (Brill, 2019) and provides a comprehensive and accessible introduction to the emerging concept of the evolution of consciousness. It presents an overarching model that moves us to a new level of meaning and understanding of our place in the world.

The essay is a response to an invitation to offer reflections on Richard Lennan’s recent book Tilling the Church for a panel at the annual gathering of the Karl Rahner Society. It situates the work within the distinctive spiritual and intellectual heritage shared by Karl Rahner, Pope Francis, and Lennan’s scholarly community and vocational home at Boston College, namely by reading it through an intentionally Ignatian lens. The review overlays the volume’s ecclesiological explorations with reference to the Spiritual Exercises and (...) to the contours of the current emphasis or re-emergence of the Ignatian tradition on a global stage given the last eleven years and the unique pulpit they provide via the Petrine Office. The piece argues that the adaptability and flexibility of the Ignatian heritage finds profound and lasting resonance with Lennan’s recent project and hopeful agenda. (shrink)

Volume 19, Issue 5, May 2019, Page 24-26.

Now, in Emergent Forms of Life and the Anthropological Voice, path-breaking scholar Michael M. J. Fischer moves the discussion to a consideration of the ...

Why do people think that someone living a morally bad life is less happy than someone living a good life? One possibility is that judging whether someone is happy involves not only attributing positive psychological states (i.e., lots of pleasant emotions, few unpleasant emotions, and satisfaction with life) but also forming an evaluative judgment. Another possibility is that moral considerations affect happiness attributions because they tacitly influence attributions of positive psychological states. In two studies, we found strong support for the (...) second hypothesis. Moral considerations only appear to affect happiness attributions when they also affect attributions of positive psychological states. Additionally, both studies supported a hypothesis about why moral judgments have these effects. Specifically, we found that when people judge that someone is living a bad life, they infer that the person is not at peace with themselves. However, when this inference is blocked, moral considerations do not affect attributions of happiness or positive psychological states. In sum, although “happiness” appears to be a purely psychological concept, happiness judgments are sensitive to moral considerations because people often assume that immorality disrupts intrapersonal harmony. (shrink)

Genome Canada has funded a research project to evaluate the usefulness of different forms of ethical analysis for assessing the moral weight of public opinion in the governance of genomics. This paper will describe a role of public consultation for ethical analysis and a contribution of ethical analysis to public consultation and the governance of genomics/biotechnology. Public consultation increases the robustness of ethical analysis with a more diverse and rich accounts experiences. Consultation must be carefully and respectfully designed to generate (...) sufficiently diverse and rich accounts of moral experiences. Since dominant groupstend to define ethical or policy issues in a manner that excludes some interests or perspectives, it is important to identify the range of interests that diverse publics hold before defining the issue and scope of a consultation. Similarly, a heavy policy focus and pressures to commercialize products risk oversimplification of the discussion and the premature foreclosure of ethical dialogue. Consequently, a significant contribution of ethical dialogue strengthened by social analysis is to consider the context and non-policy use of power to govern genomics and to sustain social debate on enduring ethical issues. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Theory of Belief Michael M. Gorman Belief is a key concept in Hume's philosophy, and yet Hume's statements aboutbeliefappear to be hopelesslyinconsistent.1 Various solutions have been offered, from saying that Hume is incorrigibly confused to saying that his theory ofbeliefchanged over the course of his career. This article will focus on the question ofthe nature ofbelief and show that Hume's theory is in fact consistent. In sections (...) 1 and 2, I will separate those passages where Hume discusses the nature of beUeffrom those where he discusses other questions. In sections 3-6, 1 will examine his theory ofthe nature ofbelief. Finally, in section 7, 1 will briefly look at his theories on other questions concerning belief. 1.Hume's statements about belief can be divided into at least nine different categories. Hume says that a beliefis: 1.an idea conceived in a certain manner (e.g., E 49, T 96); 2.that certain manner ofconception itself(e.g., E 49, T 97); 3.an idea that feels a certain way (e.g., E 48, T 103); 4.that certain feeling itself(e.g., E 49, T 624, 629); 5.an idea that has a great influence on the mind (e.g, T 118-20); 6.an act ofmind rendering realities influential on the mind (e.g., E 49, T 629); 7.a lively idea related to an impression (e.g., T 96); 8.a lively manner of conceiving an idea, which manner arises from an impression (e.g., E 50); 9.something that makes ideas forceful and vivacious (e.g., T 101, 627). If one were in a really bad mood, one could probably split Hume's formulations into even more categories.2 2.One solution wouldbe to saythat Hume ishopelessly confused.3 This is not accurate, however. The first thingtobe done is to notice thatonly the statements belonging to the first four categories are actually answers to the question, What is the nature of beUef? Hume tells us that abeUefis: an ideaconceived in acertainmanner, theverymanner ofconception ofsuch an idea, an idea thatfeels a certain way, thevery feeling of such an idea. To explicate Hume's theory of the nature of Volume XLX Number 1 89 MICHAEL M. GORMAN beUef, I will show that the second formulation is a poor version ofthe first and that the fourth formulation is a poor version ofthe third—in other words, that there are reallyonlytwo theorieshere, notfour. Then I will reconcile these two theories. As for Hume's discussion ofother questions concerning belief, the statementsin the fifth and sixth categories address the question, What does à belief do? Those in the seventh and eighth categories take for granted the statements in the first and second categories respectively and address the further question, What causes beliefs? Those in the ninth category are probably cases of bad writing. All these will be examined in section 7. 3. Let us look at the texts that fit into the first and second categories listed in section 1. These express what can be called Hume's "manner-of-conception theory" (MCT). First, Hume says that a belief is a certain kind ofidea, namely an idea conceived in a certain manner. He describes this manner ofconception by saying that such an idea is conceived with a high degree of force and vivacity, liveliness, and so forth. This analysis rests on Hume's distinction between the content of an idea and the manner in which the idea is conceived. [A]s 'tis certain there is a great difference betwixt the simple conception ofthe existence ofan object, and the beliefofit, and as this difference lies not in the parts or composition of the idea, which we conceive; it follows, that it must lie in the manner, in which we conceive it. (T 94-95) One can believe that something is the case, or one can simply conceive ofits being the case without assenting to it. In both cases, Hume says, the content ofthe idea must be the same. Otherwise, both making up one's mind and disagreeingwith someone wouldbe impossible: making up one's mind would be a transition from thinking about one thing to thinking about... (shrink)

The fair innings argument (FIA) is frequently put forward as a justification for denying elderly patients treatment when they are in competition with younger patients and resources are scarce. In this paper I will examine some arguments that are used to support the FIA. My conclusion will be that they do not stand up to scrutiny and therefore, the FIA should not be used to justify the denial of treatment to elderly patients, or to support rationing of health care by (...) age.There are six issues arising out of the FIA which are to be addressed. First, the implication that there is such a thing as a fair share of life. Second, whether it makes sense to talk of a fair share of resources in the context of health care and the FIA. Third, that 'fairness' is usually only mentioned with regard to the length of a person's life, and not to any other aspect of it. Fourth, if it is sensible to discuss the merits of the FIA without taking account of the 'all other things being equal' argument. Fifth, the difference between what is unfair and what is unfortunate. Finally, that it is tragic if a young person dies, but only unfortunate if an elderly person does. (shrink)

Physician assisted suicide or active euthanasia is analyzed as a medicalization of the needs of persons who are suffering interminably. As with other medicalized responses to personal needs, the availability of active euthanasia will likely divert attention and resources from difficult social and personal aspects of the needs of dying and suffering persons, continuing the pattern of privatization of the costs of caregiving for persons who are candidates for active euthanasia, limiting the ability of caregivers to assist suffering persons to (...) make their continued suffering tolerable, and casting doubt on the voluntariness of the choice of active euthanasia. Keywords: caregivers, euthanasia, family, medicalization, voluntariness CiteULike Connotea Del.icio.us What's this? (shrink)

In November of 2019, the University of California Santa Cruz hosted a 3-day interdisciplinary conference to commemorate the 200th anniversary of the publication of Frankenstein, by Mary Shelley. A panel of senior researchers convened to discuss the impact of the novel on modern discussions of scientific ethics. The panel featured Nandini Bhattacharya, George Blumenthal, Michael M. Chemers, David Haussler, and Jenny Reardon. In the process, the panelists acted as the Institutional Review Board for a proposal from Victor Frankenstein himself.

This paper surveys the meaning of aither in Empedocles. Since Aristotle, Empedoclean aither has been generally considered synonymous with air and understood anachronistically in terms of its Aristotelian conception as hot and wet. In critiquing this interpretation, the paper first examines the meaning of “air” in Empedocles, revealing scant and insignificant use of the term. Next, the ancient controversy of Empedocles’ “four roots” is recast from the perspective that aither, rather than air, designates the fourth root. Finally, the nineteen instances (...) of aither in Empedocles’ fragments are considered, revealing a bright and energetic root closely related to the force of life. (shrink)

In this article, I examine Thomas Aquinas's teaching on the light of glory (lumen gloriae), and attempt to resolve several problems that arise within this teaching.

Williams James’s 1903 election to the National Academy of Sciences has long been understood as well-deserved recognition for his scientific achievement and as evidence that other sciences had begun to accept the “new psychology” as a peer discipline. This note offers a detailed review of the complex course of events that led to James’s election – presented within the context of the Academy’s own history – that illustrates just how a variety of extra-scientific factors had a significant impact on this (...) tribute. It closes with a review of James’s own activities as an Academy member. (shrink)

This paper provides a detailed account of the origins of the Psycho logical Review in 1894, of the policies and practices of its editors (James Mark Baldwin and James McKeen Cattell) during its first decade, and of the public and private disagreements that led them to dissolve their collaboration in 1904. In doing so, it sheds light on the significant roles played by specialized scientific journals in the development of specific scientific specialities, and illustrates the value for historical exploration of (...) (what anthropologists call) a 'thick description' of (what historians call) 'the fine texture of the past'. It argues that personal factors such as luck and character and temperament often have a greater impact on the way in which science actually evolves than do intellectual interests and concerns, and concludes with an analysis of the overwhelming signifi cance of this episode on the later careers of both Baldwin and Cattell. (shrink)

Previous research shows that students often do not read informed consent forms to understand their rights. Four hundred fifty-eight students participated in an advertised temperament study that actually measured whether they noticed a manipulation within the consent form. Answering five questions about the form raised the percentage of students noticing the manipulation in multiple settings; however, overall rates were low. Fewer than 10% of ethnic minority students noticed the manipulation. If the goal of consent forms in higher education remains an (...) informed decision, these results indicate the need for increased interaction within the consent process. (shrink)

A suspicion about libertarian free will is that freedom is undermined, rather than supported, by the positing of indeterminism within processes of volition. In response, this paper presents a way in which moments of indeterminism can enhance freedom, by showing how such moments can genuinely belong to the agent. The key idea is that of putting the imagination to work in the service of free agency. The suggestion is that indeterministic processes of imaginative generativity can both belong to an agent, (...) and provide a ground for claims of freedom. In contrast to Robert Kane’s libertarian proposal of locating critical self-forming actions in special moments of rational choice, freedom-friendly indeterministic moments of self-shaping are instead posited within processes of imaginative generativity in which our future possibilities are imagined. This incompatibilist alternative to traditional libertarianism is briefly compared to Mele’s modest libertarianism, and defended against a selection of likely criticisms. (shrink)

St. Thomas Aquinas’ exposition of the Liber de causis, one of the few extended commentaries on this influential work, has received much greater detailed attention during recent decades. Nonetheless, interpretations have diverged concerning how this Neoplatonic source was assimilated and refined by Aquinas. It is not only important to comprehend the originality of procedures and accomplishment of St. Thomas in relation to his work for the sake of historical precision. Equally important is the intention of both the author and his (...) commentator, which is to contribute to our grasp of reality in terms of fundamental metaphysical principles. (shrink)

This book declares that lifelong learning teaches values and wholeness and rejects inert ideas or fragmentation. Education plays a vital role in reorganizing and revitalizing the abundant facts from the information explosion. Specialization works at cross-purposes with liberal arts education, which discloses a holistic vision of each person’s being.

Phenomenologists or Continental thinkers argue for the subject-object continuum. For phenomenology, subjectivity is _of_ the object, and object is _for_ the subject. This book applies that continuum to the holistic foundations of work or specialization. The author devotes a chapter to each of eight cultural applications of the subject-object continuum. Chapter One examines the specialist-generalist continuum meaning specialization _for_ general education. That continuum comprises the framework for the remaining seven chapters. Those seven include production _for_ community, design _for_ user, automation (...) _for_ user, computing _for_ society, taxation _for_ society, information _for_ manufacturing, and procedure _for _goal. These eight applications constitute the basis for a core curriculum. The core curriculum gives holistic meaning, order, or cosmos to all jobs and to all people. Cosmos is a Greek word meaning humanistic-scientific order, irreducible to physics. The core curriculum is fundamental cosmology. Each of the eight continuities follow in a logical, systematic manner from the analytic-subjective continuum meaning object _for_ subjectivity. Phenomenology of education can become the human basis of a promising holistic logic, bringing together analytic and existential themes. (shrink)

This collection of essays by a group of international scholars focuses on specific issues in bioethics and paediatrics. It reflects interdisciplinary approaches to practical problems at the level of policy and practice.

Eliminative Materialism holds that propositional attitude folk psychology is a radically false theory of human, cognition, communication and behaviour. The paper reviews the argument that Eliminative Materialism is self-defeating. Although the argument is unsuccessful, it is argued that Eliminative Materialism ought to be considered epistemically self-undermining. Eliminative Materialism's truth would undermine the epistemic warrant of the theories (from cognitive neuroscience) typically taken as motivating the eliminativist thesis. Eliminative materialism fails to recognise that, in the psychological sciences, the mind is both (...) the object and instrument of study. Radically changing the instrument changing the instrument changes the background conditions and epistemic underpinnings of all inquiry. (shrink)

This paper examines parataxis and ring composition in Anaxagoras Fragment B4a, arguing that this ostensibly prose philosopher employs these poetic techniques to capture his thought. Comparing the fragment with Homeric similes and his description of Achilles’s Shield from Ililad XVIII reveals an immanent poetics within the Anaxagorean text. Lying between two instances of "πολλά τε καὶ παντοῖα" (many things of all kinds) most of fragment constitutes a single sentence. Such ring composition advises that no part of the paratactic clause should (...) be read independently from any other. This supports reading the discussion of "seeds" (σπέρματα) and "compacted" (συμπαγῆναι) human beings in B4a as yielding a conception of infinitely proliferating microcosmic worlds each undergoing its own separation within a single cosmos. (shrink)

The multiple activities of the RecA protein in DNA metabolism have inspired over a decade of research in dozens of laboratories around the world. This effort has nevertheless failed to yield an understanding of the mechanism of several RecA protein‐mediated processes, the DNA strand exchange reactions prominent among them. The major factors impeding progress are the invalid constraints placed upon the problem by attempting to understand RecA protein‐mediated DNA strand exchange within the context of an inappropriate biological paradigm – namely, (...) homologous genetic recombination as a mechanism for generating genetic diversity. In this essay I summarize genetic and biochemical data demonstrating that RecA protein evolved as the central component of a recombinational DNA repair system, with the generation of genetic diversity being a sometimes useful byproduct, and review the major in vitro activities of RecA protein from a repair perspective. While models proposed for both recombination and recombinational repair often make use of DNA strand cleavage and transfer steps that appear to be quite similar, the molecular and thermodynamic requirements of the two processes are very different. The recombinational repair function provides a much more logical and informative framework for thinking about the biochemical properties of RecA and the strand exchange reactions it facilitates. (shrink)

The role of natural theology in St. Thomas Aquinas's early doctrine of (transcendental) trut, especially in question one of Aquinas's "Disputed Questions on Truth (De veritate).

Many viral and cellular mRNA species contain a leader sequence derived from a distant upstream site on the same gene by a process of RNA splicing. This process usually involves either nuclear functions or self‐splicing of RNA molecules. Coronavirus, a cytoplasmic RNA virus, unfolds yet another mechanism of joining RNA, which involves the use of a free leader RNA molecule. This molecule is synthesized and dissociates from the template RNA, and subsequently reassociates with the template RNA at down‐stream initiation sites (...) of subgenomic mRNAs to serve as the primer for transcription. This leader‐primed transcriptional process thus generates viral mRNAs with a fused leader sequence. A similar mechanism might also operate in the mRNA transcription of African trypanosomes. (shrink)

This paper examines the relationship between participation and motion with respect to the natural philosophy of the "Phaedo". Aristotle’s criticism of participation and its failure to account for motion shows the relevance of the dialogue to this problem. Challenging Aristotle’s critique, I interpret the "Phaedo" as offering a possible solution to the question of how forms cause motion in material beings. The verb ὀρέγεσθαι at 65c8, 75a2, and 75b1, together with the active ὀρέγειν at 117b2, ground an account of ontological (...) striving as a solution to the difficulties inherent in participation within the literary context of the dialogue. (shrink)

Collected essays on the topic of nature in the thought of St. Thomas Aquinas. Introduction by Ralph McInerny.